Keyboard: Bayesian Designs for Early Phase Clinical Trials

We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972>). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.

Version: 0.1.3
Depends: R (≥ 3.4.0), Rcpp (≥ 0.12.0), methods
Imports: Iso, ggplot2
Published: 2022-08-11
DOI: 10.32614/CRAN.package.Keyboard
Author: Xiaomeng Yuan, Chen Li, Hongying Sun, Li Tang and Haitao Pan
Maintainer: Xiaomeng Yuan <xiaomeng.yuan at>
License: GPL-2
NeedsCompilation: no
CRAN checks: Keyboard results


Reference manual: Keyboard.pdf


Package source: Keyboard_0.1.3.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): Keyboard_0.1.3.tgz, r-oldrel (arm64): Keyboard_0.1.3.tgz, r-release (x86_64): Keyboard_0.1.3.tgz, r-oldrel (x86_64): Keyboard_0.1.3.tgz
Old sources: Keyboard archive


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